2022

Dashti M, Al-Matrouk A, Channanath A, Al-Mulla F, Thanaraj TA. Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population. Sci Rep. 2022 Sep 1;12(1):14858. doi: 10.1038/s41598-022-19318-x. PMID: 36050458; PMCID: PMC9437070.

Orliaguet L, Ejlalmanesh T, Humbert A, Ballaire R, Diedisheim M, Julla JB, Chokr D, Cuenco J, Michieletto J, Charbit J, Lindén D, Boucher J, Potier C, Hamimi A, Lemoine S, Blugeon C, Legoix P, Lameiras S, Baudrin LG, Baulande S, Soprani A, Castelli FA, Fenaille F, Riveline JP, Dalmas E, Rieusset J, Gautier JF, Venteclef N, Alzaid F. Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling. Nat Commun. 2022 Aug 30;13(1):5089. doi: 10.1038/s41467-022-32813-z. PMID:36042203.

Alshawaf E, Hammad MM, Marafie SK, Ali H, Al-Mulla F, Abubaker J, Mohammad A. Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach. Microb Pathog. 2022 Aug 10;170:105701. doi: 10.1016/j.micpath.2022.105701. Epub ahead of print. PMID: 35963279; PMCID: PMC9364730.

Suleman M, Asad U, Arshad S, Rahman AU, Akbar F, Khan H, Hussain Z, Ali SS, Mohammad A, Khan A, Ali L, Wei DQ. Screening of immune epitope in the proteome of the Dabie bandavirus, SFTS, to design a protein-specific and proteome-wide vaccine for immune response instigation using an immunoinformatics approaches. Comput Biol Med. 2022 Sep;148:105893. doi: 10.1016/j.compbiomed.2022.105893. Epub 2022 Aug 7. PMID: 35961087.

Dashti M, Al-Matrouk A, Channanath A, Hebbar P, Al-Mulla F, Thanaraj TA. Distribution of HLA-B Alleles and Haplotypes in Qatari: Recommendation for Establishing Pharmacogenomic Markers Screening for Drug Hypersensitivity. Front Pharmacol. 2022 Aug 8;13:891838. doi: 10.3389/fphar.2022.891838. PMID:36003520; PMCID: PMC9393242.

Abd-Alrazaq A, Alhuwail D, Al-Jafar E, Ahmed A, Shuweihdi F, Reagu SM, Househ M. The Effectiveness of Serious Games in Improving Memory Among Older Adults With Cognitive Impairment: Systematic Review and Meta-analysis. JMIR Serious Games. 2022 Aug 9;10(3):e35202. doi: 10.2196/35202. PMID: 35943792; PMCID: PMC9399845.

Leentjens M, Alterki A, Abu-Farha M, Bosschieter PFN, de Raaff C, de Vries C, Al Shawaf E, Thanaraj TA, Al-Khairi I, Cherian P, Channanath A, Kavalakatt S, van Wagensveld BA, de Vries N, Abubaker J. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity. Front Endocrinol (Lausanne). 2022 Aug 9;13:922425. doi: 10.3389/fendo.2022.922425. PMID: 36017324; PMCID: PMC9396619.

Ramdas S, Judd J, Graham SE, ....Hebbar P, ..et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. Am J Hum Genet. 2022 Aug 4;109(8):1366-1387. doi: 10.1016/j.ajhg.2022.06.012. PMID: 35931049; PMCID: PMC9388392.

Alhammad R, Abu-Farha M, Hammad MM, Thanaraj TA, Channanath A, Alam-Eldin N, Al-Sabah R, Shaban L, Alduraywish A, Al-Mulla F, Rahman A, Abubaker J. Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers, Including Leptin, Chemerin, and High Sensitivity C-Reactive Protein. Int J Mol Sci. 2022 Aug 2;23(15):8564. doi: 10.3390/ijms23158564. PMID: 35955698; PMCID: PMC9369195.

Hammad MM, Mohammad A, Alam-Eldin N, Madhu D, Al-Mulla F, Abu-Farha M, Abubaker J. Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor. Life Sci. 2022 Aug 2:120857. doi: 10.1016/j.lfs.2022.120857. Epub ahead of print. PMID: 35931197.

Jamal MH, AlOtaibi F, Dsouza C, Al-Sabah S, Al-Khaledi G, Al-Ali W, Ali H, Cherian P, Al-Khairi I, Devarajan S, Abu-Farha M, Al-Mulla F, Abubaker J. Changes in the expression of meteorin-like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery. Obesity (Silver Spring). 2022 Aug;30(8):1629-1638. doi: 10.1002/oby.23473. Epub 2022 Jul 18. PMID: 35844163.

Al-Sayyar A, Hulme KD, Thibaut R, Bayry J, Sheedy FJ, Short KR, Alzaid F. Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity. Front Endocrinol (Lausanne). 2022 Jul 26;13:919223. doi: 10.3389/fendo.2022.919223. PMID: 35957811; PMCID: PMC9363013.

Hasan, A. Arefanian, H.Channanath, A.M. AlKhairi, I.Cherian, P. Devarajan, S. Thanaraj,T.A. Abu-Farha, M. Abubaker, J.Al-Mulla, F. Association of COVID-19 Vaccines ChAdOx1-S and BNT162b2 with Circulating Levels of Coagulation Factors and Antithrombin. Vaccines 2022, 10, 1226. https://doi.org/10.3390/ vaccines10081226

Abd-Alrazaq A, Alhuwail D, Ahmed A, Househ M. Effectiveness of Serious Games for Improving Executive Functions Among Older Adults With Cognitive Impairment: Systematic Review and Meta-analysis. JMIR Serious Games. 2022 Jul 25;10(3):e36123. doi: 10.2196/36123. PMID: 35877166.

Akhter N, Kochumon S, Hasan A, Wilson A, Nizam R, Al Madhoun A, Al-Rashed F, Arefanian H, Alzaid F, Sindhu S, Al-Mulla F, Ahmad R. IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation. J Inflamm Res. 2022 Jul 27;15:4291-4302. doi: 10.2147/JIR.S368352. PMID: 35923906; PMCID: PMC9343018.

Kochumon S, Jacob T, Koshy M, Al-Rashed F, Sindhu S, Al-Ozairi E, Al-Mulla F, Rosen ED, Ahmad R. Palmitate Potentiates Lipopolysaccharide-Induced IL-6 Production via Coordinated Acetylation of H3K9/H3K18, p300, and RNA Polymerase II. J Immunol. 2022 Jul 27:ji2100928. doi: 10.4049/jimmunol.2100928. Epub ahead of print. PMID: 35896337.

Shehab M, Alrashed F, Alfadhli A, Alsayegh A, Aldallal U, Alsayegh M, Cherian P, Alkhair I, Thanaraj TA, Channanath A, Dashti AA, Albanaw A, Ali H, Abu-Farha M, Abubaker J, Al-Mulla F. Immunogenicity of BNT162b2 Vaccine Booster Dose in Patients With Inflammatory Bowel Disease Receiving Infliximab Combination Therapy: A Prospective Observational Study. Front Med (Lausanne). 2022 Jul 4;9:933996. doi: 10.3389/fmed.2022.933996. PMID: 35860742; PMCID: PMC9289180.

Qaddoumi M, Hebbar P, Abu-Farha M, Al Somaly A, Melhem M, Al-Kayal F, AlKhairi I, Cherian P, Alanbaei M, Al-Mulla F, Abubaker J, Thanaraj TA. GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level. Genes (Basel). 2022 Jul 4;13(7):1201. doi: 10.3390/genes13071201. PMID: 35885984; PMCID: PMC9316564.

Abd-Alrazaq A, Alhuwail D, Schneider J, Toro CT, Ahmed A, Alzubaidi M, Alajlani M, Househ M. The performance of artificial intelligence-driven technologies in diagnosing mental disorders: an umbrella review. NPJ Digit Med. 2022 Jul 7;5(1):87. doi: 10.1038/s41746-022-00631-8. PMID: 35798934; PMCID: PMC9262920.

Dashti M, Nizam R, Hebbar P, Jacob S, John SE, Channanath A, Al-Kandari H, Thanaraj TA, Al-Mulla F. Differentially methylated and expressed genes in familial type 1 diabetes. Sci Rep. 2022 Jun 30;12(1):11045. doi:10.1038/s41598-022-15304-5. PMID: 35773317; PMCID: PMC9247163.