Obesity is the result of chronic energy imbalance that puts patients at high-risk of type-2 diabetes (T2D) and of its complications and comorbidities. The diabetic context itself drastically alters metabolism at multiple scales, from subcellular and cellular to microenvironmental, in different organs, and systemic, in the whole body. Energy imbalance and altered metabolism at different levels are central to progression of disease and may influence susceptibility to specific complications or comorbidities. The developing research axis for Bioenergetics at the DDI is focused on the functional and mechanistic study of metabolism and energy balance at multiple levels.
