Obesity, type 2 diabetes and associated complications are rapidly growing and representing a serious threat to Kuwaiti population as well as worldwide. The role of inflammation in Type 2 diabetes (T2D) and its co-morbidities is now clear, although the immune/metabolic markers and their pathways that promote and sustain the inflammatory process remain unclear. There is an urgent need to identify novel immune and metabolic markers in order to understand the mechanisms underlying high fat diet/overnutrition-induced inflammation and T2D and related complications.
Our goal is to build a map of the interactions between high fat dietary components, adipokines, receptors, and transcription factors, and to determine the roles of these factors (individually or interactively) in tissues and cell types relevant to human T2D. Our long-term goal is to develop novel therapeutics (pharmacology, exercise, nutrition and probiotics/microbiome) that interrupt these pathways and thus promote metabolic health.
Head of Microbiology & Immunology
1. Identify the roles of TLRs/IRF3/IRF5/IRF7/FOXO and IL-33/ST2 in inflammation/T2D, energy and glucose homeostasis, T2D and associated complications.
2. Investigate the role of high fat diet and bioactive lipids in insulin resistance/diabetes.
3. Study the epigenetic changes underlying the effects of high fat nutrients and adipokines, and their roles in inflammation and T2D.
4. Investigate the use of probiotics and dietary interventions in the prevention and treatment of diabetes and associated complications.
5. To study host-microbiome interaction and its impact on diabetes in the Kuwaiti Population
6. Study the mechanistic role TLRs/MMPs/overnutrition axis involved in etiopathogenesis of diabetic complications: neuropathic pain and cardiovascular diseases.
7. Identify the interactive associations among metabolic, inflammatory and oxidative stress markers relevant to the induction or progression of insulin resistance, T2D and associated complications.
8. Investigation the role of Toll-Like Receptors 2 and 4 in induction of NOD-Like Receptor Protein 3 (NLRP3) and inflammasome formation in pancreatic islets
9. Studying the role of adipocyte activated macrophages’ exosomes on beta cells survival and function-a model of macrophage-beta cell cross-talk in obesity and type 2 diabetes